Asociación del virus del papiloma humano en parejas

Association between human papillomavirus in men and their
sexual partners and uterine cervical intraepithelial
neoplasia
Jose´ Guzma´n-Esquivel Æ Alicia Martı´nez-Contreras Æ Mario Ramı´rez-Flores Æ
Lilia M. Jime´nez Ceja Æ Ivan Delgado-Enciso Æ Sandra Martı´nez-Garza Æ
Luz M. Baltazar Rodrı´guez
Received: 7 February 2008 / Accepted: 25 June 2008

Springer Science+Business Media, B.V. 2008
Abstract
Objectives To determine whether the presence of
human papillomavirus (HPV) in men is a risk factor
in the development of intraepithelial cervical neoplasia
in their sexual partners and to corroborate HPV
frequency and type.
Materials and methods A case-control study was
carried out in the city of Colima, Mexico, from
October 2004 to September 2005. It included the
male sexual partners of females presenting with
intraepitheleal neoplasia and with negative cervical
uterine cytology. The study was approved by the
local ethics committee, and participants signed a
letter of informed consent. Samples were taken from
the penis with a cytobrush and were analyzed by
polymerase chain reaction (PCR) with type-specific
HPV consensus primers. Statistical analysis was
carried out using averages, percentages, and chisquare
test for association.
Results Twenty-one patients and 40 controls were
analyzed. Eight were excluded due to DNA degradation.
Chi-square test was utilized to find
association between risk factor (HPV in men) in
men whose sexual partners were women with
premalignant lesions and normal Papanicolaou test.
There was no statistical significance; OR was 2.5, CI
was 0.38–16.41, and P = 0.37 (Fisher’s exact test).
There was no significant difference between the two
study groups. Four HPV-positive cases (19%) were
obtained from the case group, and two HPV-positive
cases (6%) were obtained from the control group.
The six positive samples had low-grade virus. There
was no association between HPV in men and the
cervical intraepitheleal neoplasia of their sexual
partners.
Conclusions In the present study, HPV in men was
not found to be a risk factor in the development of
cervical uterine lesions. The viruses that were found
were low risk. The sample size employed was not
large enough to be able to determine any differences
between both study groups